igf-1 long r3 is an 83 amino acid analog of human IGF-I actually comprising the complete human IGF-1 sequence but with the substitution of an Arg for the Glu at position 3, as well as a 13 amino acid extension peptide at the N-terminus. This makes Long R3IGF-I significantly more potent ( 2-3x) than IGF-I in studies, because it has a lower affinity to be rendered inactive by IGF binding proteins, and consequently more potential activity in the body
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Precaution - Keep a record of doses. If you are diabetic or using insulin or any other diabetic, sugar lowering medicine you should monitor your blood glucose closely because growth hormone may change your body response to insulin.
Keep at 2-8C. Don't freeze. Angtropin is very stable and can stay for a month in normal room temperature. But it is still advised to refrigerate whenever possible and always keep away from direct light. After dilution it must be refrigerated. In case of sterile water it must be used within 72 hours. If you dilute with bacteriostatic water you can use even after 10 days or more.
The supplementation of mammalian cell cultures with Long R3 IGF-1 at a much lower concentration results in more highly elevated productivity than with standard concentrations of insulin and/or standard IGF-1. IGF-1 LR3 is better able to stimulate the type 1 IGF receptor and thus induce a higher level of activation of intracellular signaling, which is responsible for promoting cell proliferation and the inhibition of apoptosis.